Please use this identifier to cite or link to this item:
Title: In vitro anticancer activity of Sargassum sp. polysaccharides against MCF-7 cell lines
Authors: Karthick, V.
Akhila, C.
Kumar, V. Ganesh
Subashini, D.
Dhas, T. Stalin
Govindaraju, K.
Vasanth, K.
Keywords: Polysaccharides;Spectroscopy;Apoptosis;Sargassum sp.;Adenocarcinoma
Issue Date: Aug-2019
Publisher: NISCAIR-CSIR, India
Abstract: Seaweed polysaccharides are compounds with promising chemopreventive and chemotherapeutic activities. In this study, polysaccharides isolated from Sargassum seaweeds were tested for their efficiency in cancer therapy. Polysaccharides were isolated, purified, and characterized using nuclear magnetic resonance (NMR); and Fourier transform infrared (FT-IR) spectroscopic and matrix-assisted laser desorption ionization mass spectrometric (MALDI-MS). It was found that the polysaccharides from Sargassum sp. branches are sulfated galactose–fucose disaccharides and sulfated galactose monosaccharides attached to the main chain through (1–4) linkages. Further, the polysaccharides were tested for cytotoxicity and anticancer activity against human breast adenocarcinoma cell line (MCF-7) using the Annexin-V/propidium iodide (PI) staining method.
Page(s): 1267-1273
ISSN: 0975-1033 (Online); 0379-5136 (Print)
Appears in Collections:IJMS Vol.48(08) [August 2019]

Files in This Item:
File Description SizeFormat 
IJMS 48(8) 1267-1273.pdf415.3 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.