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http://nopr.niscpr.res.in/handle/123456789/50509| Title: | Green synthesis of acetohydroxamic acid by thermophilic amidase of Bacillus smithii IIIMB2907 |
| Authors: | Singh, Rahul Vikram Sharma, Hitesh Gupta, Prasoon Kumar, Amit Babu, Vikash |
| Keywords: | Acetohydroxamic acid;Bacillus smithii IIIMB2907;Thermophilic amidase |
| Issue Date: | Oct-2019 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Acetohydroxamic acid is a pharmaceutically active metal chelating agent which has various applications in the field of medicine. Current study focuses on the enzymatic synthesis of acetohydroxamic acid catalysed by thermophilic amidase from Bacillus smithii IIIMB2907. Bacterial cells were grown in 7 L fermenter for amidase production and effect of pH, temperature and substrate concentration for the biotransformation of acetamide to acetohydroxamic acid was studied. Batch reaction was also successfully optimized at bench scale with the recovery of ≈ 81% acetohydroxamic acid (purified). |
| Page(s): | 373-377 |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Appears in Collections: | IJBB Vol.56(5) [October 2019] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJBB 56(5) 373-377.pdf | 219.29 kB | Adobe PDF | View/Open |
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