Advances in monitoring and state estimation of bioreactors

Abstract

The need to operate bioreactors in an efficient manner is becoming more relevant in today’s environment of changing process technology and increasing market competition. Better monitoring and control of bioreactors require reliable real-time available process variable information, while many of the important bioprocess variables cannot be measured on-line. On-line estimation of unknown bioprocess variables and incorporation of such variable information in process operation and control strategies can provide improved control performance with enhanced productivity. Bioprocess state estimation is thus an essential component to integrate with the process systems engineering tools such as, advanced process control, fault detection and diagnosis. This paper reviews the developments in state and parameters estimation of bioreactors from on-line monitoring and control perspective.