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http://nopr.niscpr.res.in/handle/123456789/5277| Title: | Antinociceptive effect of amitriptyline in mice of acute pain models |
| Authors: | Paudel, Keshab Raj Das, Balbhadra Prasad Rauniar, G P Sangraula, Himal Deo, Satish Bhattacharya, S K |
| Keywords: | Acute pain;Amitriptyline;Antinociception;Mice |
| Issue Date: | Jun-2007 |
| Publisher: | CSIR |
| Abstract: | Tricyclic antidepressant drugs induce antinociceptive effect and suggest that their analgesic action could be related to the monoaminergic activity of the drugs. The analgesic activity of amitriptyline was observed in mouse models of acute pain. Mice were divided into different groups and were given amitriptyline in different doses alone and in combination with morphine. Reaction time in Hot-Plate and Tail-Flick tests was observed. Results showed that amitriptyline had antinociceptive effect in acute pain state in experimental models. Amitriptyline in combination with morphine had better analgesic effect than the morphine alone in Hot-Plate test. |
| Page(s): | 529-531 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.45(06) [June 2007] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 45(6) 529-531.pdf | 33.43 kB | Adobe PDF | View/Open |
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