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http://nopr.niscpr.res.in/handle/123456789/5288Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Prasad, Ashok | - |
| dc.contributor.author | Sharma, M L | - |
| dc.contributor.author | Kanwar, Seema | - |
| dc.contributor.author | Rathee, Raman | - |
| dc.contributor.author | Sharma, S D | - |
| dc.date.accessioned | 2009-07-14T11:01:53Z | - |
| dc.date.available | 2009-07-14T11:01:53Z | - |
| dc.date.issued | 2005-10 | - |
| dc.identifier.issn | 0975-1084 (Online); 0022-4456 (Print) | - |
| dc.identifier.uri | http://hdl.handle.net/123456789/5288 | - |
| dc.description | 756-760 | en_US |
| dc.description.abstract | Nimesulide, a COX-2 selective drug, possesses anti-inflammatory and analgesic properties. Moreover, it has low gastro-intestinal and renal toxicity. This paper presents industrially viable, new and improved synthesis of nimesulide starting from o-chloro nitrobenzene. The reaction with triphenyl phosphate yields 2-phenoxy nitrobenzene (90%) followed by reduction and mesylation and finally selective nitration furnishes the drug (85%).
 | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | CSIR | en_US |
| dc.relation.ispartofseries | A61P | en_US |
| dc.source | JSIR Vol.64(10) [October 2005] | en_US |
| dc.subject | Nimesulide | en_US |
| dc.subject | Large-scale synthesis | en_US |
| dc.subject | COX-2 selective drug | en_US |
| dc.title | A practical large scale synthesis of nimesulide — A step ahead | en_US |
| dc.type | Article | en_US |
| Appears in Collections: | JSIR Vol.64(10) [October 2005] | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| JSIR 64(10) 756-760.pdf | 102.82 kB | Adobe PDF | View/Open |
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