Infertility associated with sub clinical salmonellosis

Abstract

<smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="place"> Subclinical infection of guinea pigs with isogenic wild type and <i style="">aro</i>A, <i style="">htr</i>A and <i style="">aro</i>A-<i style="">htr</i>A mutants of <i style="">Salmonella enterica</i> subspecies <i style="">enterica</i> serovar Abortusequi (<i style="">S.</i> Abortusequi) induced infertility, while mutants had little or no effect on conception rate in guinea pigs. Conception rate was significantly lower in guinea pigs inoculated with wild type (S-787) and <i style="">aro</i>A mutant of <i style="">S</i>. Abortusequi than those inoculated with intracellular survival deficient <i style="">htr</i>A or <i style="">aro</i>A-<i style="">htr</i>A mutants of <i style="">S</i>. Abortusequi. Chi-test analysis revealed that none of the three mutants could be attributed to low conception rate, but wild type <i style="">Salmonella </i>inoculation and chronic carriage of the pathogen were significant cause of low conception rate in guinea pigs. Role of <i style="">S</i>. Abortusequi in causation of infertility was proven from the experiment for the first time. </smarttagtype>