Please use this identifier to cite or link to this item:
Title: Hepatoprotective effect of Carissa carandas Linn root extract against CCl4 and paracetamol induced hepatic oxidative stress
Authors: Hegde, Karunakar
Joshi, Arun B
Keywords: Antioxidants;Carissa carandas;CCl4;Hepatoprotective activity;Oxidative stress;Paracetamol
Issue Date: Aug-2009
Publisher: CSIR
Abstract: Oral pre-treatment with ethanolic extract of the roots of C. carandas (ERCC; 100, 200 and 400 mg/kg, po) showed significant hepatoprotective activity against CCl4 and paracetamol induced hepatotoxicity by decreasing the activities of serum marker enzymes, bilirubin and lipid peroxidation, and significant increase in the levels of uric acid, glutathione, super oxide dismutase, catalase and protein in a dose dependent manner, which was confirmed by the decrease in the total weight of the liver and histopathological examination. Data also showed that ERCC possessed strong antioxidant activity, which may probably lead to the promising hepatoprotective activities of C. carandas root extract. These findings therefore supported the traditional belief on hepatoprotective effect of the roots of C. carandas.
Page(s): 660-667
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.47(08) [August 2009]

Files in This Item:
File Description SizeFormat 
IJEB 47(8) 660-667.pdf455.95 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.