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http://nopr.niscpr.res.in/handle/123456789/54565| Title: | A one pot, efficient and eco-friendly synthesis of 1,3,4-thiadiazolo[3,2-a] pyrimidine scaffold via Aza–Michael addition and intramolecular cyclo-elimination reactions in poly ethylene glycol (PEG) |
| Authors: | Ahmad, Akeel Tiwari, Shailendra |
| Keywords: | Substituted phenyl;1,3,4-thiadiazolo;Pyrimidine;Carboxylate;Carbonitrile;Antimicrobial activity;Fungicidal activity |
| Issue Date: | May-2020 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Potassium carbonate in poly (ethylene glycol-400) has been found to be a highly effective and efficient medium for the straight forward, convenient, one pot and green synthesis of ethyl 2-substituted phenyl-7-oxo-7H-[1,3,4]- thiadiazolo [3,2-a]- pyrimidine-6-corboxylate and -6-corbonitrile through intramolecular cyclo-elimination of Michael adducts formed between the reaction of 2-amino-5 substituted thiadiazoles with diethyl-2- (ethoxymethylene) malonate and ethyl-2- cyano-3-ethoxyacrylate respectively. The structures of all the new compounds have been elucidated using IR, 1H and 13C NMR, mass spectral data and elemental analyses. |
| Page(s): | 724-729 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.59B(05) [May 2020] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 59B(5) 724-729.pdf | 169.12 kB | Adobe PDF | View/Open |
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