Facile synthesis and characterization of some new 5-arylidene-thiazolidine-2,4-diones and their antimicrobial evaluation

Abstract

A series of novel 5-arylidene-thiazolidine-2,4-diones derivatives have been synthesized by the Knoevenagel condensation of aromatic aldehydes and N-substituted thiazolidinedione-2,4-diones. Use of KAl(SO₄)₂•12(H₂O) <em>i</em>.<em>e</em>. Alum for the reaction makes this synthesis facile because of several advantageous factors <em>viz</em>. non-toxicity, efficient catalytic ability and cheap cost of alum. Substitution of arylidene moiety at the position 5 on the thiazolidine-2,4-diones nucleus has occured using this facile approach. Synthesized derivatives have been characterized using various analytical tools and antimicrobial evaluation thereof has been performed against Gram-positive, Gram negative bacteria and a fungal strain. All synthesized compounds show moderate to very good activity against the microorganisms that they have been tested against.