Effect of <i style="">Curcuma longa</i> or parziquantel on <i style="">Schistosoma mansoni</i> infected mice liver — Histological and histochemical study

Abstract

Effect of drug praziquantel (PZQ) and <i style="">C. longa</i> extract on <i style="">S. mansoni</i> infected mice is reported. The level of glycogen, alkaline and acid phosphatases (ALP and ACP respectively), and body weight, liver weight and liver weight/body weight ratio were studied in mice infected with <i style="">S.mansoni</i>. ALP level was increased after infection. <i style="">C. longa</i> treated mice showed marked reduction in ALP level more than after PZQ-treatment. <i style="">C. longa</i> enhanced the concentration of glycogen after being reduced by infection, while PZQ-treatment revealed more reduction. <i style="">C. longa</i> caused enhancement in body weight while PZQ treatment had no effect. The formation of granuloma around schistosome eggs in the liver produced inflammation. <i style="">C.longa </i>extract and PZQ were effective in reducing granuloma size in infected mice.