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Title: Zoo-chemical profile analysis and cytotoxicity screening of five marine sponge species collected from Andaman and Nicobar Islands
Authors: Muthiyan, R
Perumal, P
Muniswamy, K
Bhattacharya, D
Kundu, A
Sunder, J
De, A K
Keywords: Cytotoxicity;Marine sponges;South Andaman group of islands;Zoo-chemicals
Issue Date: Aug-2020
Publisher: NISCAIR-CSIR, India
Abstract: Marine environment with vast diversity is a great natural source of many important bioactive compounds of medicinal value. In the present study, five marine sponges i.e. Hyrtios erectus, Pseudoceratina purpurea, Carteriospongia foliascens, Stylissa carteri and Axinella acanthelloides were collected from eastern coast of Andaman sea around South Andaman group of islands and their zoo-chemical profiles were analyzed. The in-vitro cytotoxic potential of the five sponge species against breast carcinoma cell line was evaluated. Alkaloid was the major zoo-chemical constituent of the sponges. Among the five sponge species studied, Hyrtios showed most promising cytotoxic effect against breast carcinoma cell line. Hexane extract of sponge inhibited the proliferation of the MCF-7 cell line. IC50 value was 25 µg per ml. The IC50 values of all the solvent extracts of all the four sponges were higher than 100 µg per ml. In conclusion, the sponge Hyrtios has huge pharmaceutical potential in the treatment of breast cancer.
Page(s): 1464-1472
ISSN: 2582-6727 (Online); 2582-6506 (Print)
Appears in Collections:IJMS Vol.49(08) [August 2020]

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