Protective responses of antioxidant enzymes against bisphenol-A induced oxidative stress in Asian Seabass Lates calcarifer

Abstract

Bisphenol A (BPA) is an endocrine disruptor used as plastic monomer and plasticizer widely present in the aquatic environment. In the present study, the effect of BPA on the antioxidant system in <em>Lates calcarifer</em> was documented. Three different concentrations such as 1, 10, 100 &micro;g/l were selected and exposed to fishes for 30 days. After BPA exposure, antioxidant parameters were estimated against control. The levels of marker enzymes were assessed in the gill, muscle, liver and brain tissues. The results showed that the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and lipid peroxidation (LPx) were increased in treated groups than control. On the other hand, reduced glutathione (GSH) level was decreased in BPA exposed groups compared to control. Based on the results, imbalance in the antioxidant defence system clearly indicated that the BPA toxicity could lead to susceptible oxidative stress in various tissues of the fish <em>L. calcarifer</em>.