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http://nopr.niscpr.res.in/handle/123456789/55461| Title: | Dihetero double Michael addition in PEG-400: Synthesis of 2,3-dihydro- [2,3-c]-[1,2,4]-triazole scaffold |
| Authors: | Tiwari, Shailendra Ahmad, Akeel Singh, Vinod Kumar |
| Keywords: | Substituted phenyl;1,3,4-thiadiazolidine;1,2,4-triazole;Malonate;Acetate;Antimicrobial activity;Fungicidal activity |
| Issue Date: | Oct-2020 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Potassium carbonate in poly (ethylene glycol-400) has been found to be a highly effective and efficient medium for the straight forward, convenient, one pot and green synthesis of diethyl/ethyl cyano-5-[substituted phenyl-2,3-dihydro-[1,3,4]-thiadiazolidino - [2, 3-c] – [1, 2, 4]-triazol -2- yl] – malonate/acetate through intramolecular cyclo- elimination of Michael adducts formed between the reaction of 4-amino-5- substituted phenyl-3-mercapto-1,2,4-triazole 1 with diethyl-2-(ethoxymethylene) malonate and ethyl -2-cyano-3-ethoxyacrylate respectively. The structures of all the new compounds have been elucidated using IR, 1H and 13C NMR, mass spectral data and elemental analyses. |
| Page(s): | 1586-1592 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.59B(10) [October 2020] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 59B(10) 1586-1592.pdf | 367.66 kB | Adobe PDF | View/Open |
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