New insights on the antifungal activity of essential oil of Salvia desoleana Atzei et Picci, an endemic plant from folk medicine of Sardinia, Italy

Abstract

This work reports the results concerning the antifungal activity of the essential oil obtained from <em>Salvia desoleana</em>, an endemic plant from folk medicine of Sardinia Island, Italy. Chemical analysis of <em>S. desoleana</em> essential oil isolated by hydrodistillation was carried out by gas chromatography (GC-FID) and gas chromatography–mass spectrometry (GC-MS). The essential oil contains high amounts of oxygenated monoterpenes and sesquiterpene hydrocarbons, being linalyl acetate (21.0%), a-terpinyl acetate (17.3%), 1,8-cineole (6.7%), linalool (3.6%), sclareol (3.5%) and germacrene D (22.1%) the main compounds. The oil was more active against the yeast <em>Cryptococcus neoformans</em> and the dermatophyte <em>Trichophyton rubrum</em> with MIC values of 0.16 μL/mL and 0.32 μL/mL, respectively. The oil revealed an important inhibitory effect on the germ tube formation in <em>C. albicans.</em> It was able to achieve about 40% of inhibition of filamentation at concentrations as low as 0.08 µL/mL. These findings add significant information to the biological activity of the essential oil of <em>S. desoleana</em>, specifically to its antifungal properties, thus justifying and reinforcing the use of this plant in traditional medicine.