Anti-oxidant potential of herbal formulation (Sahaj Vati) modulating leptin, insulin activity

Abstract

Obesity increased at alarming rate is considered as a serious health risk and the World Health Organization wishes to halt the rise of obesity. Therefore, search for the treatment and dietary mediations is fundamental to lessen or potentially forestall the corpulence. Sahaj Vati was prepared using Shilajeet, Curcuma longa, Plumbago zeylanica, Commiphora mukul and might be helpful to reduce obesity. Twenty four albino rats were randomized into four equal groups and were selected as control, positive control, as standard (orlistat) and Sahaj Vati treated group, respectively. Monosodium glutamate (MSG) was administered at a dose of 10 mg/kg body weight for 10 days and Sahaj Vati & orlistat was regulated orally at portion of 200 and 10 mg/kg body weight individually for four week. After four week, the body weight of animals, serum leptin, insulin, total oxidant, total antioxidant and oxidative stress index were estimated. It was observed that body weight was significantly increased by MSG whereas body weight was significantly decreased by orlistat and Sahaj Vati. Sahaj Vati significantly increased insulin concentration, total anti-oxidant status and decreased total oxidant status & oxidative stress and significantly decreased leptin concentration. Thus, Sahaj Vati decreases body weight by modulating leptin & insulin concentration as well as total oxidant status, total anti-oxidant status & oxidative stress.