Design, synthesis and evaluation of new colourimetric chemosensors containing quinazolinones moiety for some cations detection in an aqueous medium and biological sample

Abstract

The current project deals with designing and synthesizing of colourimetric chemosensors to detect the cations in the aqueous medium and biological sample. To achieve this goal a new series of quinazolinone derivatives have been synthesized <em>via</em> reaction of the novel 6-nitro-2-propyl-4<em>H</em>-benzo[<em>d</em>][1,3]oxazin-4-one <strong>3</strong> with selected nitrogen nucleophiles, namely, formamide, hydrazine hydrate, hydroxylamine hydrochloride, <em>o</em>-phenylendiamine, <em>o</em>-aminophenol and <em>o</em>-aminothiophenol, urea and/or thiourea. Structures of the new compounds have been investigated depending on their spectral data (IR, ¹H and ¹³C&nbsp;NMR and MS) and elemental analyses. Some of the newly synthesized products exhibit significant response as chemosensors for a few cations detection.