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dc.contributor.authorDey, Swarna Kamal-
dc.contributor.authorMiddha, Sushil Kumar-
dc.contributor.authorUsha, Talambedu-
dc.contributor.authorFoudah, Ahmed Ibrahim-
dc.contributor.authorEkambaram, Hemavathy-
dc.contributor.authorKamala, Arunagiri-
dc.contributor.authorSamuel, Rosa J-
dc.contributor.authorYusufoglu, Hasan Soliman-
dc.contributor.authorGoyal, Arvind Kumar-
dc.identifier.issn0975-1068 (Online); 0972-5938 (Print)-
dc.description.abstractBambusa tulda (Poaceae) is one of the most valuable bamboo species in terms of health-promoting effects. The goal of this research work was to carry out the in-vivo acute toxicity, anti-diabetic and anti-oxidative activities of hydro-methanolic extract of B. tulda leaves. The median lethal dose (LD50) of the hydro-methanolic extract of B. tulda leaves was found to be 6088.13 mg/kg body weight in mice. Supplementing the low (100 mg/kg) and high dose (200 mg/kg) of B. tulda leaf extract showed significant elevation in the endogenous enzymes level of superoxide dismutase (24.81%) and glutathione peroxidase (31.60%) with a decline in malondialdehyde levels (21.90%) when compared to untreated alloxan-induced diabetic control rats. The histopathological assessment of pancreas also showed an increase in β-cells, though not at a significant level. Hence the presence of phyto-constituents substantiates the pharmacological activities of hydro-methanolic extract of B. tulda leaf particularly as a potential candidate for anti-diabetic activity. However, detailed studies are needed to elucidate its exact mechanism of action against diabetes.en_US
dc.relation.ispartofseriesInt Cl.21: A61K 39/00, A61K 45/06, A61P 3/10, A61P 7/12, C12N 5/00en_US
dc.sourceIJTK Vol.20(4) [October 2021]en_US
dc.subjectBambusa tuldaen_US
dc.subjectGlutathione peroxidaseen_US
dc.subjectSuperoxide dismutaseen_US
dc.titleScientific validation of toxicological and anti-hyperglycemic effect of Bambusa tulda leafen_US
Appears in Collections:IJTK Vol.20(4) [October 2021]

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