Syntheses, spectral characterization and antidiabetic activities of oxidovanadium(V) complexes with bi-and tridentate ligands

Abstract

Four new oxidovanadium(V) complexes [VO(L1)(Mol)] (1), [VO(L2)(Mol)] (2), [VO(L3)(Mol)] (3) and [VO(L4)(Mol)] (4)(where L1-L4 = aroylhydrazones and Mol = maltol) have been synthesized with different ligands. The complexes havebeen characterized using microanalysis, spectral fab mass, UV-visible, electrochemical (cyclic voltammetry and differentialpulse voltammetry), density functional theory calculations have been performed to predict the optimized geometry, globalreactivity parameters and electron density. In these complexes, the d-d absorption band is not observed as being d0 vanadiumcentres in these complexes. The electrochemical behaviour of these complexes are explored by cyclic voltammetry anddifferential pulse voltammetry (DPV). All complexes exhibit one electron transfer i.e., reduction of vanadium(V) tovanadium(IV). These complexes are screened for in vitro α-glucosidase and α-amylase inhibition study. Complex 3 has aninteresting insulin-like activity.