1,5-Benzosulfonamide anthracenedione analogues of mitoxantrone as antibacterial and anticancer agents

Abstract

The new 1,5-disubstituted 9,10 anthraquninone compounds have been synthesized and characterized by FT-IR, 1H and 13C NMR, and mass spectrometry. Mass fragmentation pattern confirms the structure of the synthesized analogues. The synthesized compounds (B1-B5) have been found active against Hela (cervix carcinoma), prostate cancer and breast cancer cell lines in comparison to mitoxantrone. B2 screened out to be best. IC50 value of B2 and mitoxantrone against Hela cell lines have been observed to be 17μg/mL and 2.5μg/mL respectively. DNA intercalation has been proposed as per cell cycle analysis of B2 on Hela cell lines which show major alteration in G0/G1 and S phase. The results are further supported by molecular docking study of (B1-B5) compounds and mitoxantrone with quadruplex terminals i-motif. The compounds have also been evaluated for antibacterial activities.