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http://nopr.niscpr.res.in/handle/123456789/59545| Title: | Free-radical scavenging and α-glucosidase inhibitory activities of pyrazoline and pyrazole heterocyclic compounds |
| Authors: | Ramya, S Anusha, K Tiwari, A K Raju, B China |
| Keywords: | Pyrazolines;pyrazoles;free-radical scavenging;α-glucosidase inhibitory activity |
| Issue Date: | Apr-2022 |
| Publisher: | NIScPR-CSIR, India |
| Abstract: | A total of fifty pyrazolines 3a-y and pyrazoles 4a-y have been evaluated for their free-radical scavenging and α-glucosidase inhibitory activities. The pyrazolines 3e, 3h, 3p, 3s and pyrazole 4e have been identified as potent ABTS.+ free-radical scavengers. The thiophene substituted pyrazoline 3s has shown potent ABTS.+ free radical scavenging activity compared to thiophene substituted pyrazole 4s. Furanyl (4r), pyrazolyl (4t), 2-chloropyridinyl (4u-w), 2-chloroquinolinyl (4x) and 4-chlorocoumarin (4y) pyrazoles have displayed moderate ABTS.+ free-radical scavenging activity. Pyrazoline 3i and pyrazole 4b have shown moderate DPPH free-radical scavenging activity. |
| Page(s): | 399-404 |
| ISSN: | 2583-1321 (Online); 0019-5103 (Print) |
| Appears in Collections: | IJC Vol.61(04) [April 2022] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Indian J Chem, 61, 399-404 (Apr,2022).pdf | 8.21 MB | Adobe PDF | View/Open |
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