Synthesis, antimicrobial and docking studies of some novel (N1E, N2E)-N1, N2-bis(2-amino-3,5-dibromobenzylidene)-aryl-1,2-diamines

Abstract

The diamino derivative is utilized to synthesize various substituted derivatives, which are characterized by IR and NMR. The antibacterial properties of synthesized compounds have been explored. Novel (E)-4,6-dibromo-N1- (4-substitutedbenzylidene)benzene-1,2-diamine derivatives (1-6) have been obtained in good yields from 2-amino- 3,5-dibromobenzaldehyde and 4-substituted benzene-1,2 diamines in a single pot synthesis. The antimicrobial activity of the synthesized compounds have been screened against different strains such as Staphylococcus aureus, Bacillus subtilis, Streptococcus pyogenes, Klebsiella pneumoniae, Escherichia coli and compared with Ciprofloxacin as a standard and compound 6 shows significant activity against Staphylococcus aureus. The docking study results also support the antimicrobial activity data.