Design, synthesis and in vitro antimicrobial activity of fused pyridine-pyrimidine hybrids

Abstract

The antimicrobial resistance (AMR) is defined as the rising global concern of infectious illnesses that are resistant to all known antimicrobial agents. As the microbial resistance is increasing recently against the present therapeutics, there is an urgency to discover the novel antimicrobial agents. Due to this reason, we have synthesized a series of novel pyridinepyrimidine derivatives (4a-o) for the development of antimicrobial agents. The structures of these bioactive molecules were determined using IR, 1H NMR, 13C NMR, and mass spectroscopy. The titled compounds were tested for antimicrobial activity against various bacterial and fungal strains using Chloramphenicol and Griseofulvin as standard drugs. Compounds 4b, 4d and 4m exhibited excellent antibacterial activity with MIC = 62.5 μg/mL against E. coli, S. aureus and S. pyogenes respectively. Compounds 4g and 4o showed prominent activity against C. albicans with MIC value of 250 μg/mL.