In vitro evaluations of antimicrobial, cytotoxicity, DNA binding, cholinesterase studies of copper complexes with phenyl-selanyl ligands

Abstract

Copper (II) complexes (3a-i) with (16E)-N-(2-phenylquinolin-4(1H)-ylidine)-2-(phenylselanyl)pyridine-3-amine ligands have been synthesized. They have been characterised by various spectroscopic studies. In-vitro cytotoxic potential has been determined, with significant cytotoxicity against MCF-7 cell line. The copper complexes interact with the calf thymus, (CT-DNA), according to absorption spectra and viscosity measurements. In addition, the copper complexes have been tested for their antimicrobial activity against three Gram-negative bacteria; Proteus vulgaris, Klebsiella pneumoniae, and Shigella flexneri, three Gram-positive bacteria; Staphylococcus aureus, Staphylococcus epidermidis, and Bacillus subtilis, and three fungi; Aspergillus fumigatus, Aspergillus clavatus and Candida albicans. The ligand's acetylcholinesterase (AChE) inhibiting function has been investigated in order to determine the ligand's efficacy in the treatment of neurodegenerative disorders. When compared to standard Rivastigmine and Galantamine, the synthesised ligand 2c show selective inhibition (AChE and BuChE) with IC50 values of 0.19 and 3.03 μM. The egg albumin method is used to test the anti-inflammatory efficiency and α-glucosidase inhibitory activities of copper chelates are tested.