Please use this identifier to cite or link to this item:
Title: Anti-tyrosinase, anti-elastase, and antioxidant activities of some symmetric bisthiocarbohydrazone compounds
Authors: Kaya, Yeliz
Sacan, Ozlem
Erçağ, Ayşe
Yanardag, Refiye
Keywords: Thiocarbohydrazone;isatin;antityrosinase;antielastase;antioxidant
Issue Date: Aug-2022
Publisher: NIScPR-CSIR,India
Abstract: Symmetric bisthiocarbohydrazone compounds (1, 2, 3) were obtained by the condensation of thiocarbohydrazide with carbonyl compounds such as isatin (a heterocyclic ketone) and two hydroxyl aldehydes (2-hydroxybenzaldehyde, 2-hydroxy-1- naphthaldehyde) respectively, according to the previously reported methods. These synthesized compounds were evaluated in terms of their anti-tyrosinase, anti-elastase and antioxidant potentials in vitro. All of the tested compounds exhibited antityrosinase and anti-elastase activities. It was observed that the inhibition increased with the increase of bisthiocarbohydrazone concentrations. Compound 1 showed the highest anti-tyrosinase activity. The anti-tyrosinase activity is decreasing in the following order; 2<3<1. Compound 1 showed also the highest anti-elastase activity. The anti-elastase activity is decreasing as 3<2<1. As a result, the most effective compound in terms of anti-tyrosinase and anti-elastase activities is bisthiocarbohydrazone derived from isatin. Compounds 2 and 3 with the hydroxyl substitution showed antioxidant activity close to Trolox. These compounds were found to have significant reducing effects and to be effective scavengers of DPPH.
Page(s): 895-900
ISSN: 2583-1321 (Online); 0019-5103 (Print)
Appears in Collections:IJC Vol.61(08) [August 2022]

Files in This Item:
File Description SizeFormat 
IJC 61(8) 895-900.pdf618.13 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.