An efficient sodium chloride-catalyzed synthesis of bis(indolyl) methanes in green solvent and their antibacterial evaluation

Abstract

A series of bis(indolyl)methanes derivatives have been synthesized using an efficient sodium chloride-catalyst in aqueous medium. Herein, substituted aldehydes have been successfully condensed with indole in an aqueous medium. Sodium chloride serves as an efficient and green catalyst as it is freely available and environmentally benign. Water used as green solvent also has no negative impact on the environment. The experiment follows a simple reaction procedure and completion of the reaction is achieved within 3-4 hours. The synthesized compounds have also been evaluated for their in vitro antibacterial property using 4 strains of bacteria, namely Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Klebsiella pneumonia where Streptomycin is used as the reference standard.