Study of biophysical properties, synthesis and biological evaluations of new thiazolidine-2,4-dione conjugates

Abstract

Thiazolidine-2,4-dione and its derivatives are acting as antimicrobial and antitubercular agents. Computational approach 2D-QSAR is used for prediction of antitubercular activity of the synthetic derivatives. 2D-QSAR generated model using PLSR method which predicted the statistically significant r2 = 0.3333, q2= 0.4000, pred_r2 = -1.9753 and F test = 3.0000. 2D-QSAR generated equation of pMICs is denoted the antitubercular activity correlated with thermodynamic descriptor T_2_2_O. Pharmacokinetic properties absorption, distribution, metabolism, excretion are also predicted which are useful for design the derivatives. A designed derivatives of (Z)-2-(5-substituted-2,4-dioxothiazolidin-3-yl)-N-(4-methoxy-6-methyl- 1,3,5-triazin-2-yl)acetamide (C1-C10) are synthesized and spectrally characterized using IR, 1H NMR, 13C NMR and mass spectral data analysis as well as biologically evaluated against antitubercular and antimicrobial activities. From the biologically evaluated derivatives, compounds C1 and C4 were found to be active against the different antimicrobial species. Compounds C7 and C10 are more progressive than others against antitubercular species.