Effects of patient-controlled analgesia using dexmedetomidine combined with sufentanil on caesarean section and hemodynamics

Abstract

This study evaluates the effects of patient-controlled analgesia (PCA) using dexmedetomidine combined with sufentanil on caesarean section and maternal hemodynamics. In this study, a total of 140 eligible puerperal are randomly divided into control and experimental groups (n=70). Control group has received PCA using sufentanil, while experimental group has received PCA using dexmedetomidine plus sufentanil. The analgesic and sedative effects have been evaluated using Bruggemann comfort scale(BCS) score and Ramsay score, respectively. Maternal hemodynamics-related indices heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and oxyhemoglobin saturation (SpO2) have been detected at the end of operation (T0), upon access to analgesic pump (T1), 24 h after access to analgesic pump (T2) and 48h after access to analgesic pump (T3). The incidence rates of postoperative complications were compared. It has been found that at T2 and T3, BCS and Experimental group had significantly higher Ramsay score and lower HR, SBP, DBP and SpO2 than those of control group (P<0.05). The incidence rate of complications in experimental group (5.71%) is found to be significantly lower than that of control group (22.86%) (P<0.05).