Feasible pathways for the multi-dimensional synthesis of carboxylic acid from benzo-pyrone methyl ketone

Abstract

3-Acetyl coumarin derivatives are the key synthons to the numerous numbers of heterocyclic compound syntheses.Due to the wide spectrum applications of benzopyran derivatives in pharma, research, food technology and material science there is a multitude number of methodologies feasible to synthesize benzo pyrone heterocyclic derivatives. This article articulates the synthesis and molecular structure confirmation of oxidative product starting from methyl ketone compound by haloform reaction. Design of benign path ways for instance room temperature, reflux conditions and water bath mediated synthesis of desired compounds in expected yields is the foremost intent of the article. Solvent and catalyst optimization studies were carried to elevate the product yield and to precede the reaction in sustainable way. Furthermore compounds are confirmed by spectroscopic analytical methods such as 1H NMR, 13C NMR, IR and HRMS spectroscopy. This article paves the way to researchers to explore these analogues to explore disparate medicinal applications.