Synthesis and bio-evaluation of novel acyl derivatives of karanjin

Abstract

Different lipidic moieties such as 10-undecenoic, oleic, lipoic, caproic, caprylic and lauric acids have been acylated to demethylated karanjin to prepare six lipoconjugated karanjin. All the derivatives have been evaluated for antimicrobial, anticancer and antiinflammatory activities and compared with karanjin and its demethylated analog. Lipoconjugation does not seem to improve the activity of karanjin against studied bacterial and fungal strains. However, karanjin, demethylated karanjin and six lipoconjugated karanjin show moderate to good anticancer activity against prostate and breast cancer cell lines. Mild antiinflammatory response has also been observed in case of karanjin and lipoic acid-conjugated karanjin.