Ru(II)/PEG-400: A green synthesis of indolyl-oxindoles and indolyl-cyclohexanedione hybrids as potential antimicrobial agents

Abstract

A green and sustainable methodology has been successfully employed for the synthesis of 3-Indolyl-3-hydroxy oxindoles and 3-indolyl-3-hydroxy-5,5-dimethylcyclohexane-1,3-dione derivatives using Ru(II)/PEG-400 as a homogeneous recyclable catalytic system from substituted isatin with indole and dimedone. Short reaction time, simple extraction procedure, substrate scope with high yield of the product, biodegradable solvent and recyclability of the catalyst without loss of its activity enhances the efficiency of the proposed protocol. The synthesized compounds are studied for their antimicrobial activity.