Hepatoprotective activity of Mitragyna speciosa Korth. on liver damage

Abstract

This study aims to evaluate the protection and restoration capacity of kratom leaves extracts on liver damage caused by tuak. Group A consist of 12 mice and divided into A1 administered 0.5 mL/20 g body weight aquadest, A2 administered kratom leaves ethanol extract at dose 0.29 mg/20 g body weight and A3 administered silymarin at dose 0.70 mg/20 g body weight on days 1 to 7, then continued given tuak at dose 0.26 mL/20 g body weight on days 8 to 14. Group B consist of 12 mice and divided into B1, B2, and B3, on days 1 to 7 they were administered tuak at dose 0.26 mL/20 g body weight then continued with aquadest at dose 0.5 mL/20 g body weight (B1), kratom leaves ethanol extract at dose 0.29 mg/20 g body weight (B2), and silymarin at dose 0.70 mg/20 g body weight on days 8 to 14 (B3). The average levels of ALT enzyme in the treatment groups respectively showed 29.13±0.40 U/L (A1); 25.25±0.69 U/L (A2); 20.51±1.00 U/L (A3) and 31.20±0.47 U/L (B1); 26.95±0.62 U/L (B2); 23.31±0.89 (B3) (p<0.05). Whereas, the average levels of AST respectively at 34.23±0.63 U/L (A1); 28.64±0.40 U/L (A2); 25.13±0.83 U/L (A3) and 35.69±0.63 U/L (B1); 30,83±0.63 (B2); 27.31±0.83 (B3) (p<0.05). The average scoring for the treatment groups resulted in 2.67; 2.33; 1.33 respectively A1, A2, and A3 (p<0.01) and 2.00; 0.67; 0.33 respectively B1, B2 and B3 (p<0.01). It is concluded that kratom leaves are not effective to protect and to restore the liver.