Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/61779| metadata.dc.identifier.doi: | https://doi.org/10.56042/ijc.v62i4.416 |
| Title: | Novel high yielding route for the synthesis of Melphalan dimer impurity G |
| Authors: | Rane, R A Male, R D Babhulkar, G V Suryawanshi, M R Kumar, Dileep Chindhe, S Pawar, D Moharir, S R Patil, R K |
| Keywords: | Melphalan;Impurity;Synthesis;Dimer impurity;Antineoplastic agent |
| Issue Date: | Apr-2023 |
| Publisher: | NIScPR-CSIR, India |
| Abstract: | Melphalan dimer is an impurity from the synthesis of Melphalan (M216900) which is an antineoplastic agent. In this article, a new route for the synthesis of Melphalan dimer impurity G has been discussed. The new research provides the first high-yield, high-purity synthesis of this impurity. The impurity has been confirmed for purity using HPLC, and its structure has been identified using MS, ¹H and ¹³C NMR. |
| Page(s): | 313-317 |
| ISSN: | 2583-1321 (Online); 0019-5103 (Print) |
| Appears in Collections: | IJC Vol.62(04) [Apr 2023] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJC 62(04) 313-317.pdf | 5.03 MB | Adobe PDF | View/Open | |
| IJC 62(04) 313-317_Supp. Info.pdf | 796.67 kB | Adobe PDF | View/Open |
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