Syntheses and characterizations of 2-nitrobenzaldehyde amino acid Schiff base reductive amination compounds

Abstract

Condensation of 2-nitrobenzaldehyde with five amino acid compounds (valine, glycine, leucine, aspartic acid, and glutamic acid) gives the corresponding Schiff bases, which upon treatment with sodium borohydride afford the reductive amination products 1−5. Compounds 1−5 have been well characterized by FT-IR and 1H NMR spectroscopic techniques, in addition to X-ray crystallography, from which the structure of compound 2 has been established. Compound 2 crystallizes in monoclinic space group P21/c, with a = 12.215(8), b = 8.096(5), c = 10.608(7) Å, β = 115.324(7), and Z = 4.