Synthesis of alkaloids 3,3’-(pyridin-2-yl)methylene)bis(1H-sustituted-indole) via infra red irradiation as heating and their evaluation antifungal against Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus

Abstract

Herein is reported a comparative study of a series of new alkaloids structurally related to turbomycin, namely 3,3'- (pyridin-2-yl)methylene)bis(1H-indole) 15, 3,3’-(pyridin-2-yl)methylene)bis(1-methyl-1H-indole) 16, 3,3’-(pyridin-2- yl)methylene)bis(2-methyl-1H-indole) 17 and 3,3’-(pyridin-2-yl)methylene)bis(2-phenyl-1H-indole) 18, compounds that have been synthesized through infra red irradiation as an efficient green activation process. In addition, these diindolylmethanes have been evaluated against levaduriform fungi (Candida albicans (ATCC 10231) and Cryptococcus neoformans (ATCC 36556)) and filamentous fungi (Aspergillus fumigatus (ATCC 13073)), with the 3,3’-(pyridin-2-yl) methylene)bis(2-phenyl-1H-indole) 15 derivative being the one exhibiting the best activity of the series. The derivatives 15- 18 exhibit a Minimum Inhibitory Concentrations (MIC) > 900 for C. albicans and C. neoformans ≤ 600.