A study on synthesis, antioxidant, anticancer activities and docking study of novel benzimidazoloyl thiazole derivatives

Abstract

2-(Substituted-amino)-5-(1-methylbenzimidazol-2-oyl)thiazoles have been synthesized by the reaction of 2-(2- bromoacetyl)-1-methylbenzimidazole and 1-(substituted-amino)-3-(N,N-dimethylimidoyl)thioureas in the presence of triethyl amine. The structure of the newly synthesized benzmidazoloyl thiazole analogues have been confirmed by spectroscopic techniques. The in vitro antioxidant activity has been studied using DPPH assay and anticancer activity has been studied using MTT assay against human colon adenocarcinoma cells. In silico studies have been performed to predict the binding modes of the compounds with the cyclin-dependent kinase protein 5FGK. It is evident from the current results that all the synthesized compounds exhibit remarkable antioxidant and anticancer potential.