Design, synthesis and in vitro antimicrobial activity of furan-based pyrimidinethiazolidinones as potential bioactive molecules

Abstract

Antimicrobial resistance (AMR) to currently available drugs is a major source of worry for researchers. Antibiotic treatment is insufficient and ineffective against many bacteria and fungi as a result of antimicrobial resistance. Novel antimicrobial drugs that can successfully combat microbial resistance are urgently needed. In order to assess their antimicrobial activity, furan-based thiazolidinone and pyrimidine scaffolds (8a–o) have been developed and synthesized. IR, 1H and 13C NMR, and mass spectrometry have been used to characterize the structures of the newly synthesized analogues (8a–o). The synthesized compounds have been tested for their antimicrobial properties against diverse bacterial and fungal strains. At MIC 12.5 μg/mL, compound 8k shows efficacy against E. coli. Compounds 8d and 8e demonstrate antifungal activity against A. niger at 100 μg/mL. Chloramphenicol, ciprofloxacin and griseofulvin have been employed as reference drugs.