Schiff base metal complex synthesis, characterization, and antimicrobial application

Abstract

There is a wide variety of biological activity that may be shown by complexes of mixed ligands with transition metal ions. Schiff bases, which are compounds that include an azomethine (C=N) group and amino acids, are very versatile molecules that may be used in the construction of ternary complexes. All three novel metal complex derivatives from the 4-(5-((2-hydroxybenzylidene)amino)-1,3,4-thiadiazol-2-yl)benzonitrile in alcoholic medium have been effectively synthesised by combining HL with the metal ions Mg(II), Zn(II) and Sn(II). Elemental analysis, molecular weight, magnetic moment and spectroscopic methods have been used to characterise the prepared complexes. Biological evaluation of the ligand and its metal complexes has demonstrated weak to significant antibacterial activity, relative to the standard antibiotic (Kanamycin). The prepared metal bound complexes are bactericidal to a greater extent than the corresponding unbounded Schiff base ligand.