Design, synthesis, characterization and biological evaluation of some azetidinone derivatives containing pyrimidine moiety

Abstract

A novel family of 3-chloro-4-benzylidene-1-(pyrimidin-2-yl) azetidin-2-one 5a-o has been developed because antimicrobial resistance (AMR) poses a significant concern to global public health and has made it exceedingly difficult to effectively manage infectious diseases that have been connected to it. The structures of the relevant compounds have been determined and verified using spectral methods. As substances are tested against gram-positive and gram-negative strains of bacteria and fungi, results must be compared to those of conventional drugs. Products with chloro substituents in both the p-position and the m-position demonstrate good activity against the fungi Aspergillus niger and Fusarium javanicum, while those with nitro, methyl, and bromo substituents in the benzene ring's p-position, as well as those with the nitro group at the ring's m-position, demonstrate excellent activitiy against bacterial strains.