One-pot, three-component synthesis of pyrimidine heterocyclic derivatives using reusable zinc ferrite catalyst and molecular docking study

Abstract

A series of pyrimidine heterocyclic compounds have been synthesized through a one-pot, three- component reaction of an aryl aldehyde, ketone and urea in the presence of nano zinc ferrite catalyst under conventional heating methods. The synthesized derivatives have been characterized by using spectral techniques such as FT-IR, 1H and 13C NMR and elemental analysis. Molecular docking studies have also been carried out to identify the protein–ligand interactions and binding affinity of the newly synthesized compounds. This work has multiple advantages of providing good yields, high efficiency and retrievable catalyst.