Design, synthesis, characterization and biological evaluation, of some novel (E)-6-(benzyloxy)-2-(4-bromobenzylidene)-7-methylbenzofuran-3(2H)-one derivatives

Abstract

Synthesis of aurones and their derivatives have attracted considerable attention due to their significant biological effects investigated along with their corresponding chalcones against some bacterial as well as fungal strains. Title compound 6-(benzyloxy)-2-[(substitutedphenyl)methylidene]-7-methyl-1-benzofuran-3(2H)-one (2a-i) have been synthesized from 1-[4-benzyloxy-2-hydroxy-3-methyl phenyl]-3-(substituted phenyl)prop-2-en-1-one. The structural assignment of the compounds was based on elemental analysis and IR, 1H NMR, LC Mass, and 13C NMR spectral data. All the synthesized compounds have been screened for their antimicrobial activity to gram-positive and gram-negative bacterial strains and antifungal activity. The antimicrobial activities of the synthesized compounds have been compared with standard drugs like Gentamycin and K. Nystatin. Purity of synthesized compounds has been checked by TLC.