Design, synthesis and antitubercular activity of pyrazole and benzo[d]imidazole clubbed dihydroimidazo[1,2-a]pyrimidinones

Abstract

The discovery and development of new pharmaceutically active drugs by medicinal chemists is being impeded by the emerging issue of antimicrobial resistance. It has triggered the urgent necessity for the generation of new medicinally active compounds. In addition, novel dihydroimidazo[1,2-a]pyrimidinone containing clubbed pyrazole and benzo[d]imidazole derivatives (5a-o) have been developed, synthesized, and tested for their antitubercular efficacy. IR, 1H and 13C NMR, and mass spectroscopy are among the analytical methods used to establish structures of the novel compounds. Mycobacterium TB H37Rv strain has been used in the antitubercular screening. The most effective derivatives (5c and 5h) against the tested strain have MIC values of 50 μg/mL. The MIC values of the further derivatives 5a, 5b, 5e, 5f, 5g, 5i, and 5l ranged from 62.5 to 125 μg/mL.