Sulpha drugs based heterochelates: Synthesis, spectroscopic, thermal and in vitro biological studies

Abstract

In the current study, dapsone and different 4-acyl pyrazolone derivatives have been used to synthesise various Cu(II) and Ni(II) based heterochelates. Elemental analysis, 1H NMR, IR, and mass spectroscopy have been utilized to check the structure of the tetra dentate DPL1 to DPL5 ligands, and FAB mass spectroscopy as well as temperature investigations (TGA/DTG and DSC) have been utilized to approve the structure of the Cu(II) and Ni(II) heterochelates. All the synthesized compounds have been examined for their in vitro biological study against two Gram +ve (Bacillus cereus, Bacillus megaterium) and two Gram –ve (Escherichia coli, Enterobacter aerogene) microorganisms as well as their MIC against two Gram +ve (Bacillus subtilis, Staphylococcus aureus) and two Gram –ve (Escherichia coli, Serratia marcescens) microorganisms. The outcomes demonstrate the tremendous promise and importance of novel bis-pyrazolone heterochelates based on dapsone for further study.