Synthesis and antimicrobial screening of 4<i style="">H</i>-2-acetyl-3-acetyamido furo[3,2-<i style="">c</i>] benzopyran 4-one, 11<i style="">H</i> -2,4-dimethyl-3,4-dihydro-3-amino-4-hydroxy-pyrimido [3,2-<i style="">d</i>]furo [3,2-<i style="">c</i>] benzopyran-11-one and 4<i style="">H</i>-2-acetyl-3-(3´-methyl-1´,2´,4´-triazol-4´-yl) furo[3,2-<i style="">c</i>] benzopyran 4-one

Abstract

<b style=""> </b>A suspension of 4<i style="">H</i>-2-acetyl-3-amino furo [3,2-<i>c</i>] benzopyran 4-one <b style="">5a-d</b> in aqueous sodium hydroxide is treated with acetyl chloride to give 4<i style="">H</i>-2-acetyl-3-acetylamido furo[3,2-<i style="">c</i>] benzopyran 4-one <b style="">6a-d</b>. The compounds <b style="">6a-d</b> and hydrazine hydrate in absolute alcohol is refluxed to give 11<i style="">H</i>-2,4-dimethyl-3,4-dihydro-3-amino-4-hydroxy-pyrimido[3,2-<i style="">d</i>] furo [3,2-<i style="">c</i>]benzopyran-11-one <b style="">7a-d </b>which<b style=""> </b>in formic acid is refluxed for 5 hr to give 4<i style="">H</i>-2-acetyl-3-(3´-methyl-1´,2´,4´-triazol-4´-yl) furo[3,2-<i style="">c</i>] benzopyran 4-one <b style="">8a-d</b>. The structures of all these compounds have been established on the basis of the spectral and analytical data. All compounds have showed good antimicrobial activity.