<i>Tamarindus indica</i> L. and <i>Moringa oleifera</i> M. extract administration ameliorates fluoride toxicity in rabbits

Abstract

Aqueous extracts of <i>T. indica</i> fruit pulp (100 mg/ kg body weight) and <i>M. oleifera</i> seeds (50 mg/ kg body weight) orally once daily for 90 days lowered plasma fluoride concentrations in rabbits receiving fluorinated drinking water (200 mg NaF/ Liter water). Cortical indices and metaphysial width in animals receiving extracts also revealed beneficial effects of plant extracts. Changes in plasma biochemistry suggested less hepatic and renal damages in animals receiving plant extracts along with fluorinated water in comparison to that receiving fluorinated water alone. Preliminary results revealed these plant extracts have some potential to mitigate fluoride toxicity.