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http://nopr.niscpr.res.in/handle/123456789/654| Title: | Synthesis and antimicrobial activity of novel linearly fused 5-substituted- 7-acetyl-2,6-dimethyloxazolo [4,5-f]indoles |
| Authors: | Donawade, Dundappa S Raghu, A V Gadaginamath, Guru S |
| Keywords: | Indoles;Hydroxylamine;Mono-oximes;Antibacterial activity;Antifungal activity |
| Issue Date: | Apr-2007 |
| Publisher: | CSIR |
| IPC Code: | Int. Cl. ⁸ C07D |
| Abstract: | The exclusive formation of 1-substituted-6-⍺-oximinoethylindoles 3a-d from the reaction of 3,6-diacetylindoles with hydroxylamine reveals the chemoselectivity of C₆-acetyl function over that of C₃-acetyl function towards the nucleophilic attack of hydroxylamine. These monooximes 3a-d are stirred with methanesulphonyl chloride in dry pyridine at room temperature to give the novel 5-substituted-7-acetyl-3,6- dimethyloxazolo[4,5-f]indoles 5a-d in good yields. The structures of all these newly synthesised compounds have been confirmed by their spectral and analytical data and they have been screened for antibacterial and antifungal activities. |
| Page(s): | 690-693 |
| ISSN: | 0376-4699 |
| Appears in Collections: | IJC-B Vol.46B(04) [April 2007] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 46B(4) (2007) 690-693.pdf | 55.65 kB | Adobe PDF | View/Open |
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