<smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="State"><smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="place"> Synthesis of a modified peptide fragment analog Val-Tyr (<i>P</i>)-Val-Ala-Ala-OH of cAMP protein kinase regulatory sub unit type II employing Fmoc chemistry </smarttagtype></smarttagtype>

Abstract

The synthesis of new peptide fragment analog (Val-Tyr(<i>P</i>)-Val-Ala-Ala-OH) incorporating Tyr into the phosphorylation site of the cAMP protein kinase regulatory sub unit type II in place of Ser (Val-Ser(<i>P</i>)-Val-Ala-Ala-OH) has been described. The phosphopentapeptide fragment is prepared by Fmoc chemistry employing the global phosphorylation method. The yield (68%) as well as purity of the final peptide is satisfactory. The peptide is fully characterized by HPLC, NMR and mass spectral data.