Synthesis and studies of novel homoveratryl based thiohydantoins as antibacterial as well as anti-HIV agents

Abstract

N,N′-bis(3,4-dimethoxyphenylethyl)-5-(arylidene)-2-thiohydantoins <b>3a-j</b> have been prepared by condensation of 1,3-diaryl-2-thiohydantoin 2 with various aromatic aldehydes. The compound <b>2</b> has been prepared by the reaction of N,N′-bis(3,4-dimethoxyphenylethyl)thiourea <b>1</b> with chloroaceticacid. The compounds have been tested for their antibacterial and anti-HIV activities against different microorganisms. The structures of novel synthesized compounds have been established on the basis of elemental analyses, ¹H NMR, IR and mass spectral data.