Rare earth transition metal-based coordination compounds of Schiff base derived from sulpha drug molecules: Synthesis, spectroscopic and in vitro biological screening

Abstract

In order to create novel transition metal-based coordination compounds, Schiff bases based on the sulpha drugs have been reacted with various 2-hydroxy-benzaldehyde derivatives. The antibacterial properties and spectroscopic attributes of the synthesized ligands and their heterochelates have been extensively examined. The structural characterization of the ligands has been accomplished through 1H NMR, IR, mass spectrometry, UV-Vis spectroscopy and elemental analysis, while the heterochelates’ structures have been validated using IR spectroscopy. In vitro evaluations have been conducted to assess the activity of the ligands and heterochelates against Gram +ve bacteria (S. aureus, B. subtilis), Gram –ve bacteria (E. coli, P. aeruginosa), and against the fungus A. niger. The findings underscore the promising nature of coordination compounds based on transition metals and highlight the necessity for further exploration in this field.