Synthesis, characterization and biological activity of Zn, Co, Ni, Mn and Cu complexes with (E)-3-(1-(2-(4,6-dimethylpyrimidin-2-yl)hydrazone)ethyl-2- hydroxy-6-methyl-4H-pyran-4-one

Abstract

The DHA derivatives of heterocyclic ring system has potent anti-microbial, anti-fungal, anti-bacterial and anti-cancer characteristics in addition to significant chelating characteristics with several metal ions. The current study involves the synthesis of Schiff base metal complexes using the pyrimidine heterocyclic system and dehydroacetic acid (DHA) with ions of Co2+, Ni2+, Cu2+, Mn2+ and Zn2+. The hydrazone ligand is coordinated with the metal complexes of Co2+, Ni2+, Cu2+, Mn2+ and Zn2+ ions, as determined from the 1H NMR, Mass, UV and FT-IR spectra, via O and N donor atoms with deprotonation of the -OH functional group. The ligand-to-metal complexes ratio has been found to be 2:1 using mass spectral data. This article describes the HOMO and LUMO orbitals of their energies. Synthesized metal complexes of Cu2+ and Zn2+ are shown to have remarkable antibacterial activity. All of the various metal complexes exhibit greater antibacterial activity when compared to free hydrazone.