Greener synthesis, molecular docking, antimicrobial and antimalarial activities of some unsaturated ketones

Abstract

A series of α,β-unsaturated ketones including isoquinoline enones have been synthesised by fly-ash:sulphated SnO2 catalyzed Crossed-Aldol condensation of various aryl methyl ketones and aldehydes under solvent-free microwave irradiation technique. In this synthetic methodology, the obtained yield of the unsaturated ketones is more than 90%. The synthesised ketones have been characterized by their physical constants, micro analysis and spectroscopic data. The molecular docking and, in vitro antimicrobial and antimalarial activities of the synthesised ketones have been studied.